Dialogue between estrogen receptor and E2F signaling pathways: The transcriptional coregulator RIP140 at the crossroads

Estrogen receptors and E2F transcription factors are the key players of two nuclear signaling pathways which exert a major role in oncogenesis, particularly in the mammary gland. Different levels of dialogue between these two pathways have been deciphered and deregulation of the E2F pathway has been shown to impact the response of breast cancer cells to endocrine therapies. The present review focuses on the transcriptional coregulator RIP140/NRIP1 which is involved in several regulatory feed-back loops and inhibitory cross-talks between different nuclear signaling pathways. RIP140 regulates the transactivation potential of estrogen receptors and E2Fs and is also a direct transcriptional target of these transcription factors. Published data highlight the complex regulation of RIP140 expression at the transcriptional level and its potential role in transcription cross-talks. Indeed, a subtle regulation of RIP140 expression levels has important consequences on other transcription networks targeted by this coregulator. Another level of regulation implies titration mechanisms by which activation of a pathway leads to sequestration of the RIP140 protein and thus impinges other gene regulatory circuitries. Altogether, RIP140 occupies a place of choice in the dialogue between nuclear receptors and E2Fs, which could be highly relevant in various human pathologies such as cancer or metabolic diseases.

Synthesis, Regulatory Factors, and Signaling Pathways of Estrogen

Rb and SRC-2 act through AF-1 transactivation domain of NGFI-B. A

Rb and SRC-2 act through AF-1 transactivation domain of NGFI-B. A

The Multifaceted Mechanisms of Estradiol and Estrogen Receptor

Stéphan Jalaguier's research works

Rb activates POMC transcription through the Nur- Response-Element

Effect of Carboxyamidotriazole Orotate, a Modulator of Calcium-Dependent Signaling Pathways, on Advanced Solid Tumors

Nuclear receptor selectivity of Rb enhancement. Rb synergizes with

PDF) From molecular action to physiological outputs: Peroxisome

Vincent CAVAILLÈS, French Institute of Health and Medical Research, Inserm, Montpellier Cancer Research Institute IRCM

Estrogen Signaling and Cardiovascular Disease

Aurélie Docquier's research works Cherry Biotech, Rennes and other places

Patrick AUGEREAU, Institut de Recherche en Cancerologie de Montpellier, Montpellier, U896

Cytoplasmic Receptor-Interacting Protein 140 (RIP140) interacts with perilipin to regulate lipolysis

PDF) From molecular action to physiological outputs: Peroxisome