Dialogue between estrogen receptor and E2F signaling pathways: The

Estrogen receptors and E2F transcription factors are the key players of two nuclear signaling pathways which exert a major role in oncogenesis, particularly in the mammary gland. Different levels of dialogue between these two pathways have been deciphered and deregulation of the E2F pathway has been shown to impact the response of breast cancer cells to endocrine therapies. The present review focuses on the transcriptional coregulator RIP140/NRIP1 which is involved in several regulatory feed-back loops and inhibitory cross-talks between different nuclear signaling pathways. RIP140 regulates the transactivation potential of estrogen receptors and E2Fs and is also a direct transcriptional target of these transcription factors. Published data highlight the complex regulation of RIP140 expression at the transcriptional level and its potential role in transcription cross-talks. Indeed, a subtle regulation of RIP140 expression levels has important consequences on other transcription networks targeted by this coregulator. Another level of regulation implies titration mechanisms by which activation of a pathway leads to sequestration of the RIP140 protein and thus impinges other gene regulatory circuitries. Altogether, RIP140 occupies a place of choice in the dialogue between nuclear receptors and E2Fs, which could be highly relevant in various human pathologies such as cancer or metabolic diseases.

The mechanisms involved in the resistance of estrogen receptor

Cyclin-Dependent Kinases 4/6 signaling pathways mediated cell

Patrick AUGEREAU, Institut de Recherche en Cancerologie de Montpellier, Montpellier, U896

Dialogue between estrogen receptor and E2F signaling pathways: The

Effect of Carboxyamidotriazole Orotate, a Modulator of Calcium-Dependent Signaling Pathways, on Advanced Solid Tumors

Vincent CAVAILLÈS, French Institute of Health and Medical Research, Inserm, Montpellier Cancer Research Institute IRCM

Catherine TEYSSIER, Senior Researcher, Doctor of Philosophy, Institut de Recherche en Cancerologie de Montpellier, Montpellier, Signalisation Nucléaire et Cancer (SNeC)

Free Download Dialogue Between Estrogen Receptor And E2F Signaling

Revisiting the estrogen receptor pathway and its role in endocrine

Dialogue between estrogen receptor and E2F signaling pathways: The transcriptional coregulator RIP140 at the crossroads

Dialogue between estrogen receptor and E2F signaling pathways: The transcriptional coregulator RIP140 at the crossroads - Advances in Bioscience and Biotechnology - SCIRP

Cytoplasmic Receptor-Interacting Protein 140 (RIP140) interacts with perilipin to regulate lipolysis

Dynamic modelling of oestrogen signalling and cell fate in breast

Effect of Carboxyamidotriazole Orotate, a Modulator of Calcium-Dependent Signaling Pathways, on Advanced Solid Tumors

Stéphan Jalaguier's research works Institut de Recherche en Cancerologie de Montpellier, Montpellier and other places