Mitotane (2,4′-DDD), an isomer of DDD and derivative of dichlorodiphenyltrichloroethane (DDT), is an antineoplastic agent, can be used to research adrenocortical carcinoma. Mitotane exert its adrenocorticolytic effect at least in part through lipotoxicity induced by intracellular free cholesterol (FC) accumulation. Mitotane can have direct pituitary effects on corticotroph cells. Mitotane can induce CYP3A4 gene expression via steroid and xenobiotic receptor (SXR) activation, and has agent-agent interactions. - Mechanism of Action & Protocol.
Mitotane cancer drug molecule. Skeletal formula Stock Vector Image & Art - Alamy
Mitotane, CAS#:53-19-0
Frontiers Synergistic Killing of Polymyxin B in Combination With the Antineoplastic Drug Mitotane Against Polymyxin-Susceptible and -Resistant Acinetobacter baumannii: A Metabolomic Study
Two-dimensional chromatography for enantiomeric analysis of mitotane and its metabolite o,p′-DDA in patients with adrenocortical carcinoma indicates enantioselective metabolism - ScienceDirect
Mitotane Tablets Exporter,Wholesale Mitotane Tablets Supplier from Delhi India
Mitotane CancerIndex
Mitotane - an overview
Mitotane-d8 (2,4′-DDD-d8), Stable Isotope
Frontiers The Effects of Cumulative Dose and Polymorphisms in CYP2B6 on the Mitotane Plasma Trough Concentrations in Chinese Patients With Advanced Adrenocortical Carcinoma
Effects of adrenolytic mitotane on drug elimination pathways assessed in vitro
Mitotane Lipid Nanocarriers and Enantiomers
Separations, Free Full-Text
